| Gene Information | |
|---|---|
| Gene Name | KDM4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1064 |
| Protein Names | Lysine-specific demethylase 4A (EC 1.14.11.66) (EC 1.14.11.69) (JmjC domain-containing histone demethylation protein 3A) (Jumonji domain-containing protein 2A) ([histone H3]-trimethyl-L-lysine(36) demethylase 4A) ([histone H3]-trimethyl-L-lysine(9) demethylase 4A) |
| Target Name | lysine-specific demethylase 4a |
| Target Type | Patented-recorded target |
| Gene Age | 680 ( ENSG00000066135 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75164 |
| Gene Card | KDM4A |
| Uniprot ID | O75164 |
| Pfam | PF02373; PF02375; PF18104 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999955397) |
| Ortholog in Animals | Alpaca_ KDM4A ( ortholog_one2one ) Dog_ KDM4A ( ortholog_one2one ) Macaque_ KDM4A ( ortholog_one2one ) Mouse_ Kdm4a ( ortholog_one2one ) Pig_ KDM4A ( ortholog_one2one ) Rat_ Kdm4a ( ortholog_one2one ) Rabbit_ KDM4A ( ortholog_one2one ) |
| Ohnologs | KDM4C, KDM4B, KDM4D |
| Paralogs | JARID2, KDM4C, KDM4F, KDM4E, KDM4B, KDM4D, KDM5B, KDM5C, KDM5D, KDM5A |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15927959}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.005405(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2GF7 (X-ray 2.20A ) 2GFA (X-ray 2.10A ) 2GP3 (X-ray 2.35A ) 2GP5 (X-ray 2.28A ) 2OQ6 (X-ray 2.00A ) 2OQ7 (X-ray 2.15A ) 2OS2 (X-ray 2.30A ) 2OT7 (X-ray 2.13A ) 2OX0 (X-ray 1.95A ) 2P5B (X-ray 1.99A ) 2PXJ (X-ray 2.00A ) 2Q8C (X-ray 2.05A ) 2Q8D (X-ray 2.29A ) 2Q8E (X-ray 2.05A ) 2QQR (X-ray 1.80A ) 2QQS (X-ray 2.82A ) 2VD7 (X-ray 2.25A ) 2WWJ (X-ray 2.60A ) 2YBK (X-ray 2.40A ) 2YBP (X-ray 2.02A ) 2YBS (X-ray 2.32A ) 3NJY (X-ray 2.60A ) 3PDQ (X-ray 1.99A ) 3RVH (X-ray 2.25A ) 3U4S (X-ray 2.15A ) 4AI9 (X-ray 2.25A ) 4BIS (X-ray 2.49A ) 4GD4 (X-ray 2.33A ) 4URA (X-ray 2.23A ) 4V2V (X-ray 2.00A ) 4V2W (X-ray 1.81A ) 5A7N (X-ray 2.39A ) 5A7O (X-ray 2.15A ) 5A7P (X-ray 2.28A ) 5A7Q (X-ray 2.00A ) 5A7S (X-ray 2.20A ) 5A7W (X-ray 2.27A ) 5A80 (X-ray 2.28A ) 5ANQ (X-ray 2.00A ) 5D6W (X-ray 1.99A ) 5D6X (X-ray 2.15A ) 5D6Y (X-ray 2.29A ) 5F2S (X-ray 2.08A ) 5F2W (X-ray 2.60A ) 5F32 (X-ray 2.05A ) 5F37 (X-ray 2.22A ) 5F39 (X-ray 2.65A ) 5F3C (X-ray 2.06A ) 5F3E (X-ray 2.16A ) 5F3G (X-ray 2.50A ) 5F3I (X-ray 2.24A ) 5F5I (X-ray 2.63A ) 5FPV (X-ray 2.44A ) 5FWE (X-ray 2.05A ) 5FY8 (X-ray 2.34A ) 5FYC (X-ray 2.26A ) 5FYH (X-ray 2.35A ) 5FYI (X-ray 2.10A ) 5LY1 (X-ray 2.50A ) 5LY2 (X-ray 2.43A ) 5TVR (X-ray 2.09A ) 5TVS (X-ray 2.75A ) 5VAR (X-ray 1.83A ) 5VGI (X-ray 2.07A ) 5VMP (X-ray 2.48A ) 6CG1 (X-ray 2.16A ) 6CG2 (X-ray 2.34A ) 6G5W (X-ray 1.83A ) 6G5X (X-ray 1.78A ) 6H4O (X-ray 2.25A ) 6H4P (X-ray 2.19A ) 6H4Q (X-ray 2.31A ) 6H4R (X-ray 2.14A ) 6H4S (X-ray 2.45A ) 6H4T (X-ray 2.38A ) 6H4U (X-ray 2.21A ) 6H4V (X-ray 2.15A ) 6H4W (X-ray 2.81A ) 6H4X (X-ray 2.34A ) 6H4Y (X-ray 2.38A ) 6H8P (X-ray 1.98A ) 6HGT (X-ray 2.33A ) 7D4A (X-ray 2.20A ) 7EQV (X-ray 2.60A ) |
| DBSNP | rs586339 rs12759032 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959, ECO:0000269|PubMed:16024779}. |
| Mouse PG classification | NA |
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