| Gene Information | |
|---|---|
| Gene Name | KDM3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1761 |
| Protein Names | Lysine-specific demethylase 3B (EC 1.14.11.65) (JmjC domain-containing histone demethylation protein 2B) (Jumonji domain-containing protein 1B) (Nuclear protein 5qNCA) ([histone H3]-dimethyl-L-lysine(9) demethylase 3B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000120733 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7LBC6 |
| Gene Card | KDM3B |
| Uniprot ID | Q7LBC6 |
| Pfam | PF02373 |
| In ASD | no |
| Allosteric Prediction | no (-0.942649269) |
| Ortholog in Animals | Alpaca_ KDM3B ( ortholog_one2one ) Dog_ KDM3B ( ortholog_one2one ) GuineaPig_ KDM3B ( ortholog_one2one ) Macaque_ KDM3B ( ortholog_one2one ) Mouse_ Kdm3b ( ortholog_one2one ) Pig_ KDM3B ( ortholog_one2one ) Rat_ Kdm3b ( ortholog_one2one ) Rabbit_ KDM3B ( ortholog_one2one ) |
| Ohnologs | JMJD1C, KDM3A |
| Paralogs | JMJD1C, HR, KDM3A |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver. {ECO:0000269|PubMed:11087669, ECO:0000269|PubMed:11687974}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4C8D (X-ray 2.18A ) 5R7X (X-ray 1.44A ) 5RAA (X-ray 1.57A ) 5RAB (X-ray 1.52A ) 5RAC (X-ray 1.73A ) 5RAD (X-ray 1.90A ) 5RAE (X-ray 1.88A ) 5RAF (X-ray 1.62A ) 5RAG (X-ray 1.52A ) 5RAH (X-ray 1.66A ) 5RAI (X-ray 1.54A ) 5RAJ (X-ray 1.61A ) 5RAK (X-ray 1.69A ) 5RAL (X-ray 1.68A ) 5RAM (X-ray 2.05A ) 5RAN (X-ray 1.95A ) 5RAO (X-ray 1.59A ) 5RAP (X-ray 1.90A ) 5RAQ (X-ray 1.85A ) 5RAR (X-ray 1.47A ) 5RAS (X-ray 1.58A ) 5RAU (X-ray 1.73A ) 5RAV (X-ray 1.77A ) 5RAW (X-ray 1.55A ) 5RAX (X-ray 2.01A ) 5RAY (X-ray 1.63A ) 5RAZ (X-ray 1.81A ) 5RB0 (X-ray 1.95A ) 5RB1 (X-ray 1.76A ) 5RB2 (X-ray 1.52A ) 5RB3 (X-ray 1.53A ) 5RB4 (X-ray 1.55A ) 5RB5 (X-ray 1.51A ) 5RB6 (X-ray 1.63A ) 5RB7 (X-ray 1.57A ) 6RBJ (X-ray 2.09A ) |
| DBSNP | rs6865472 rs1762257015 rs1334033128 rs1762639635 rs7706614 rs1763530961 |
| Subcellular location [CC] | Nucleus {ECO:0000250}. |
| Mouse PG classification | NA |
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