| Gene Information | |
|---|---|
| Gene Name | KDM1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 852 |
| Protein Names | Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A) |
| Target Name | lysine-specific histone demethylase 1 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000004487 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O60341 |
| Gene Card | KDM1A |
| Uniprot ID | O60341 |
| Pfam | PF01593; PF04433 |
| In ASD | yes |
| Allosteric Prediction | yes (0.722709742) |
| Ortholog in Animals | Alpaca_ KDM1A ( ortholog_one2one ) Dog_ KDM1A ( ortholog_one2one ) GuineaPig_ KDM1A ( ortholog_one2one ) Macaque_ KDM1A ( ortholog_one2one ) Mouse_ Kdm1a ( ortholog_one2one ) Pig_ KDM1A ( ortholog_one2one ) Rat_ Kdm1a ( ortholog_one2one ) Rabbit_ KDM1A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAOA, SMOX, PPOX, KDM1B, PAOX, MAOB, IL4I1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:16079795}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.034862(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2COM (NMR - ) 2DW4 (X-ray 2.30A ) 2EJR (X-ray 2.70A ) 2H94 (X-ray 2.90A ) 2HKO (X-ray 2.80A ) 2IW5 (X-ray 2.57A ) 2L3D (NMR - ) 2UXN (X-ray 2.72A ) 2UXX (X-ray 2.74A ) 2V1D (X-ray 3.10A ) 2X0L (X-ray 3.00A ) 2XAF (X-ray 3.25A ) 2XAG (X-ray 3.10A ) 2XAH (X-ray 3.10A ) 2XAJ (X-ray 3.30A ) 2XAQ (X-ray 3.20A ) 2XAS (X-ray 3.20A ) 2Y48 (X-ray 3.00A ) 2Z3Y (X-ray 2.25A ) 2Z5U (X-ray 2.25A ) 3ABT (X-ray 3.20A ) 3ABU (X-ray 3.10A ) 3ZMS (X-ray 2.96A ) 3ZMT (X-ray 3.10A ) 3ZMU (X-ray 3.20A ) 3ZMV (X-ray 3.00A ) 3ZMZ (X-ray 3.00A ) 3ZN0 (X-ray 2.80A ) 3ZN1 (X-ray 3.10A ) 4BAY (X-ray 3.10A ) 4CZZ (X-ray 3.00A ) 4KUM (X-ray 3.05A ) 4UV8 (X-ray 2.80A ) 4UV9 (X-ray 3.00A ) 4UVA (X-ray 2.90A ) 4UVB (X-ray 2.80A ) 4UVC (X-ray 3.10A ) 4UXN (X-ray 2.85A ) 4XBF (X-ray 2.80A ) 5AFW (X-ray 1.60A ) 5H6Q (X-ray 2.53A ) 5H6R (X-ray 2.60A ) 5IT3 (X-ray 1.40A ) 5L3B (X-ray 3.30A ) 5L3C (X-ray 3.31A ) 5L3D (X-ray 2.60A ) 5L3E (X-ray 2.80A ) 5L3F (X-ray 3.50A ) 5L3G (X-ray 3.10A ) 5LBQ (X-ray 3.30A ) 5LGN (X-ray 3.20A ) 5LGT (X-ray 3.00A ) 5LGU (X-ray 3.20A ) 5LHG (X-ray 3.34A ) 5LHH (X-ray 3.05A ) 5LHI (X-ray 3.40A ) 5X60 (X-ray 2.69A ) 5YJB (X-ray 2.96A ) 6E1F (X-ray 1.16A ) 6K3E (X-ray 2.87A ) 6KGK (X-ray 2.70A ) 6KGL (X-ray 2.70A ) 6KGM (X-ray 2.62A ) 6KGN (X-ray 2.62A ) 6KGO (X-ray 2.25A ) 6KGP (X-ray 2.25A ) 6KGQ (X-ray 2.32A ) 6KGR (X-ray 2.32A ) 6NQM (X-ray 2.90A ) 6NQU (X-ray 2.70A ) 6NR5 (X-ray 2.90A ) 6S35 (X-ray 3.10A ) 6TE1 (X-ray 3.11A ) 6TUY (X-ray 2.60A ) 6VYP (X-ray 4.99A ) 6W4K (X-ray 2.93A ) 6WC6 (X-ray 3.10A ) 7CDC (X-ray 2.64A ) 7CDD (X-ray 2.76A ) 7CDE (X-ray 2.68A ) 7CDF (X-ray 2.68A ) 7CDG (X-ray 2.80A ) 7E0G (X-ray 2.25A ) 7JJL (X-ray 2.60A ) 7JJM (X-ray 2.06A ) 7JK7 (X-ray 1.96A ) 7VQS (X-ray 2.94A ) 7VQT (X-ray 2.91A ) 7VQU (X-ray 2.94A ) |
| DBSNP | rs864309715 rs864309716 rs864309714 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11102443, ECO:0000269|PubMed:16079795, ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:33980486}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |