| Gene Information | |
|---|---|
| Gene Name | NSMF |
| Organism | Homo sapiens (Human) |
| Gene Length | 530 |
| Protein Names | NMDA receptor synaptonuclear signaling and neuronal migration factor (Nasal embryonic luteinizing hormone-releasing hormone factor) (Nasal embryonic LHRH factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000165802 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q6X4W1 |
| Gene Card | NSMF |
| Uniprot ID | Q6X4W1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.905999771) |
| Ortholog in Animals | Alpaca_ NSMF ( ortholog_one2one ) Dog_ NSMF ( ortholog_one2one ) GuineaPig_ NSMF ( ortholog_one2one ) Macaque_ NSMF ( ortholog_one2one ) Mouse_ Nsmf ( ortholog_one2one ) Pig_ NSMF ( ortholog_one2one ) Rat_ Nsmf ( ortholog_one2one ) Rabbit_ NSMF ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in adult and fetal brain. Weakly expressed in heart, liver, spleen, testis, small intestine, skeletal muscle, peripheral white blood cells and kidney. {ECO:0000269|PubMed:15362570, ECO:0000269|PubMed:20025934}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs770597015 rs121918340 rs34177733 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20025934}. Nucleus envelope {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:20025934}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:20025934}; Peripheral membrane protein {ECO:0000269|PubMed:20025934}. Cell projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Postsynaptic density {ECO:0000250}. Membrane {ECO:0000250}. Note=Found on the outside of the luteinizing-hormone-releasing hormone (LHRH) cell membrane and axons projecting from the olfactory pit and epithelium. Associates with transcriptionally active chromatin regions. Detected at the nuclear membranes of CA1 neurons. Cortical cytoskeleton. Localized in proximal apical dendrites. Colocalizes with CABP1 in dendrites and dendritic spines. Myristoylation is a prerequisite for extranuclear localization. Translocates from dendrites to the nucleus during NMDA receptor-dependent long-term potentiation (LTP) induction of synaptic transmission at Schaffer collateral/CA1 synapses of hippocampal primary neurons and in a importin-dependent manner (By similarity). {ECO:0000250}. |
| Mouse PG classification | HPG |
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