| Gene Information | |
|---|---|
| Gene Name | KDELR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 212 |
| Protein Names | ER lumen protein-retaining receptor 2 (ERD2-like protein 1) (ELP-1) (KDEL endoplasmic reticulum protein retention receptor 2) (KDEL receptor 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000136240 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P33947 |
| Gene Card | KDELR2 |
| Uniprot ID | P33947 |
| Pfam | PF00810 |
| In ASD | no |
| Allosteric Prediction | no (-0.190253379) |
| Ortholog in Animals | Alpaca_ KDELR2 ( ortholog_one2one ) Dog_ KDELR2 ( ortholog_one2one ) GuineaPig_ KDELR2 ( ortholog_one2one ) Macaque_ KDELR2 ( ortholog_one2one ) Mouse_ Kdelr2 ( ortholog_one2one ) Pig_ KDELR2 ( ortholog_one2one ) Rat_ Kdelr2 ( ortholog_one2one ) Rabbit_ KDELR2 ( ortholog_one2one ) |
| Ohnologs | KDELR3, KDELR1 |
| Paralogs | KDELR3, KDELR1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1265005474 rs1785976222 rs1785501859 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:1325562, ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Golgi apparatus membrane {ECO:0000269|PubMed:1325562, ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:18086916}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5ZKX9}. Note=Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L. {ECO:0000269|PubMed:1325562, ECO:0000305|PubMed:18086916}. |
| Mouse PG classification | NA |
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