| Gene Information | |
|---|---|
| Gene Name | KCTD6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 237 |
| Protein Names | BTB/POZ domain-containing protein KCTD6 (KCASH3 protein) (Potassium channel tetramerization domain-containing protein 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000168301 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8NC69 |
| Gene Card | KCTD6 |
| Uniprot ID | Q8NC69 |
| Pfam | PF02214 |
| In ASD | no |
| Allosteric Prediction | no (-0.433401056) |
| Ortholog in Animals | Alpaca_ KCTD6 ( ortholog_one2one ) Dog_ KCTD6 ( ortholog_one2one ) GuineaPig_ KCTD6 ( ortholog_one2one ) Macaque_ KCTD6 ( ortholog_one2one ) Mouse_ Kctd6 ( ortholog_one2one ) Pig_ KCTD6 ( ortholog_one2one ) Rat_ Kctd6 ( ortholog_one2one ) Rabbit_ KCTD6 ( ortholog_one2one ) |
| Ohnologs | KCTD1, KCTD4, KCTD21 |
| Paralogs | KCTD16, KCTD21, KCTD7, KCNRG, KCTD8, KCTD15, KCTD14, KCTD12, KCTD18, KCTD1, KCTD4, KCTD11, KCTD19 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in cerebellum and brain. Expression is down-regulated in medulloblastoma. {ECO:0000269|PubMed:21472142}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:22573887}. Note=Colocalizes with ANK1 isoform Mu17 at the M line in differentiated skeletal muscle cells and heart. {ECO:0000269|PubMed:22573887}. |
| Mouse PG classification | NA |
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