Gene Information
Gene NameTNFRSF14
OrganismHomo sapiens (Human)
Gene Length283
Protein NamesTumor necrosis factor receptor superfamily member 14 (Herpes virus entry mediator A) (Herpesvirus entry mediator A) (HveA) (Tumor necrosis factor receptor-like 2) (TR2) (CD antigen CD270)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000157873 )
3 ( ENSG00000273936 )
Evolutionary StageMammalia
AlphaFoldDBQ92956
Gene CardTNFRSF14
Uniprot IDQ92956
PfamPF00020
In ASDno
Allosteric Predictionno (-0.040234985)
Ortholog in AnimalsAlpaca_ TNFRSF14 ( ortholog_one2one )
Dog_ TNFRSF14 ( ortholog_one2one )
GuineaPig_ Tnfrsf14 ( ortholog_one2one )
Macaque_ TNFRSF14 ( ortholog_one2one )
Mouse_ Tnfrsf10b ( ortholog_one2many )
Mouse_ Tnfrsf14 ( ortholog_one2many )
Rat_ Tnfrsf10b ( ortholog_one2many )
Rat_ Tnfrsf14 ( ortholog_one2many )
OhnologsNA
ParalogsTNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF1B
TissueNA
Tissue SpecificityWidely expressed, with the highest expression in lung, spleen and thymus. Expressed in a subpopulation of B cells and monocytes (PubMed:18193050). Expressed in naive T cells (PubMed:19915044). {ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19915044}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1JMA  (X-ray  2.65A  )  2AW2  (X-ray  2.80A  )  4FHQ  (X-ray  2.25A  )  4RSU  (X-ray  2.30A  )  5T2Q  (X-ray  1.90A  )  5T2R  (X-ray  2.10A  )  6NG3  (X-ray  2.88A  )  7MSG  (X-ray  3.50A  ) 
DBSNP rs4870  rs2234163  rs11573986  rs2234167 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:19915044};
Single-pass type I membrane protein {ECO:0000305}.
Mouse PG classificationNA
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