| Gene Information | |
|---|---|
| Gene Name | KCNQ5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 932 |
| Protein Names | Potassium voltage-gated channel subfamily KQT member 5 (KQT-like 5) (Potassium channel subunit alpha KvLQT5) (Voltage-gated potassium channel subunit Kv7.5) |
| Target Name | potassium voltage-gated channel subfamily kqt member 5 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000185760 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NR82 |
| Gene Card | KCNQ5 |
| Uniprot ID | Q9NR82 |
| Pfam | PF00520; PF03520 |
| In ASD | no |
| Allosteric Prediction | yes (0.704547326) |
| Ortholog in Animals | Alpaca_ KCNQ5 ( ortholog_one2one ) Dog_ KCNQ5 ( ortholog_one2one ) GuineaPig_ KCNQ5 ( ortholog_one2one ) Macaque_ KCNQ5 ( ortholog_one2one ) Mouse_ Kcnq5 ( ortholog_one2one ) Pig_ KCNQ5 ( ortholog_one2one ) Rat_ Kcnq5 ( ortholog_one2one ) Rabbit_ KCNQ5 ( ortholog_one2one ) |
| Ohnologs | KCNQ2, KCNQ3, KCNQ4 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | brain, thyroid |
| Tissue Specificity | Strongly expressed in brain and skeletal muscle. In brain, expressed in cerebral cortex, occipital pole, frontal lobe and temporal lobe. Lower levels in hippocampus and putamen. Low to undetectable levels in medulla, cerebellum and thalamus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6B8Q (X-ray 2.60A ) |
| DBSNP | rs1135401955 rs1314919218 rs1135401956 rs1135401958 rs1135401957 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10787416, ECO:0000269|PubMed:11159685}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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