Gene Information
Gene NameKCNQ4
OrganismHomo sapiens (Human)
Gene Length695
Protein NamesPotassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4)
Target Namevoltage-gated potassium channel kv7.4
Target TypeLiterature-reported target
Gene Age645 ( ENSG00000117013 )
Evolutionary StageEumetazoa
AlphaFoldDBP56696
Gene CardKCNQ4
Uniprot IDP56696
PfamPF00520; PF03520
In ASDno
Allosteric Predictionyes (0.379371651)
Ortholog in AnimalsAlpaca_ KCNQ4 ( ortholog_one2one )
Dog_ KCNQ4 ( ortholog_one2one )
GuineaPig_ KCNQ4 ( ortholog_one2one )
Macaque_ KCNQ4 ( ortholog_one2one )
Mouse_ Kcnq4 ( ortholog_one2one )
Pig_ KCNQ4 ( ortholog_one2one )
Rat_ Kcnq4 ( ortholog_one2one )
Rabbit_ KCNQ4 ( ortholog_one2one )
OhnologsKCNQ2, KCNQ3, KCNQ5
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
TissueNA
Tissue SpecificityExpressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2OVC  (X-ray  2.07A  )  4GOW  (X-ray  2.60A  )  6N5W  (X-ray  2.15A  )  7BYL  (EM  2.50A  )  7BYM  (EM  3.10A  )  7BYN  (EM  3.30A  )  7VNP  (EM  2.79A  )  7VNQ  (EM  2.96A  )  7VNR  (EM  2.80A  ) 
DBSNP rs80358276  rs80358277  rs80358278  rs28937588  rs28937588  rs137853969  rs28939710  rs34287852 
Subcellular location [CC]Basal cell membrane;
Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO:0000250}.
Mouse PG classificationHPG
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