Gene Information
Gene NameKCNQ2
OrganismHomo sapiens (Human)
Gene Length872
Protein NamesPotassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)
Target Namepotassium voltage-gated channel subfamily kqt member 2
Target TypeNA
Gene Age544 ( ENSG00000075043 )
3 ( ENSG00000281151 )
Evolutionary StageEumetazoa
AlphaFoldDBO43526
Gene CardKCNQ2
Uniprot IDO43526
PfamPF00520; PF03520; PF11956
In ASDyes
Allosteric Predictionyes (1.000231825)
Ortholog in AnimalsAlpaca_ KCNQ2 ( ortholog_one2one )
Dog_ KCNQ2 ( ortholog_one2one )
GuineaPig_ KCNQ2 ( ortholog_one2one )
Mouse_ Kcnq2 ( ortholog_one2one )
Pig_ KCNQ2 ( ortholog_one2one )
Rat_ Eef1a2 ( ortholog_one2one )
OhnologsKCNQ4, KCNQ3, KCNQ5
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
Tissuebrain, testis, cerebral.cortex
Tissue SpecificityIn adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal cord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors. {ECO:0000269|PubMed:10781098}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5J03  (X-ray  2.00A  )  6FEG  (NMR  -  )  6FEH  (NMR  -  )  7CR0  (EM  3.10A  )  7CR1  (EM  3.40A  )  7CR2  (EM  3.20A  )  7CR3  (EM  3.60A  )  7CR4  (EM  3.90A  )  7CR7  (EM  3.70A  ) 
DBSNP rs1057516076  rs1057516078  rs1057516081  rs1057516080  rs118192199  rs796052623  rs118192200  rs74315391  rs118192201  rs796052626  rs397514581  rs118192203  rs28939684  rs1057516089  rs118192204  rs1057516091  rs118192205  rs74315392  rs1057519536  rs1057516094  rs1057516095  rs28939683  rs1057519535  rs118192211  rs1057516099  rs74315390  rs118192216  rs118192218  rs1057516110  rs796052650  rs267607198  rs796052665  rs1057516123  rs118192235  rs118192237  rs118192240  rs748400155  rs1801475 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10788442, ECO:0000269|PubMed:9836639};
Multi-pass membrane protein {ECO:0000255}.
Mouse PG classificationNA
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