Gene Information
Gene NameKCNQ1
OrganismHomo sapiens (Human)
Gene Length676
Protein NamesPotassium voltage-gated channel subfamily KQT member 1 (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1) (Voltage-gated potassium channel subunit Kv7.1)
Target Namevoltage-gated potassium channel kv7.1
Target TypeSuccessful target
Gene Age544 ( ENSG00000053918 )
3 ( ENSG00000282076 )
Evolutionary StageEumetazoa
AlphaFoldDBP51787
Gene CardKCNQ1
Uniprot IDP51787
PfamPF00520; PF03520
In ASDyes
Allosteric Predictionyes (1.693318234)
Ortholog in AnimalsAlpaca_ KCNQ1 ( ortholog_one2one )
Dog_ KCNQ1 ( ortholog_one2one )
GuineaPig_ KCNQ1 ( ortholog_one2one )
Macaque_ KCNQ1 ( ortholog_one2one )
Mouse_ Kcnq1 ( ortholog_one2one )
Pig_ KCNQ1 ( ortholog_one2one )
Rat_ Kcnq1 ( ortholog_one2one )
Rabbit_ KCNQ1 ( ortholog_one2one )
OhnologsNA
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
TissueNA
Tissue SpecificityAbundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3BJ4  (X-ray  2.00A  )  3HFC  (X-ray  2.45A  )  3HFE  (X-ray  1.70A  )  4UMO  (X-ray  3.00A  )  4V0C  (X-ray  2.86A  )  6MIE  (NMR  -  )  6UZZ  (EM  3.10A  )  6V00  (EM  3.10A  )  6V01  (EM  3.90A  ) 
DBSNP rs199473442  rs199473443  rs199473671  rs199473446  rs199472676  rs199472678  rs199472679  rs120074191  rs199472681  rs199472682  rs199473449  rs199472685  rs199472686  rs199473450  rs120074192  rs199473451  rs199472688  rs143709408  rs199472690  rs199473453  rs199472692  rs179489  rs199472694  rs199472695  rs199472696  rs199472697  rs199472697  rs120074177  rs120074177  rs199473394  rs199473661  rs199473397  rs199473398  rs104894252  rs120074178  rs120074178  rs199473662  rs199473401  rs199472698  rs199472699  rs150172393  rs199472700  rs199472701  rs199472702  rs199472703  rs199473455  rs199472704  rs17215479  rs199472706  rs199473456  rs199473457  rs199472709  rs199472710  rs199473458  rs199472711  rs199472712  rs199472713  rs120074196  rs120074196  rs397508123  rs199473459  rs199472715  rs199472715  rs120074179  rs120074179  rs199472717  rs199472718  rs199472719  rs199472720  rs199472720  rs199472721  rs199472722  rs199472723  rs199472724  rs199473460  rs199472725  rs120074194  rs120074193  rs199472726  rs120074180  rs199472727  rs199472728  rs199472729  rs199472730  rs199473461  rs199472730  rs199472731  rs199473462  rs199472732  rs199472733  rs199473463  rs199472735  rs199473464  rs199472736  rs199472737  rs199472738  rs120074187  rs193922365  rs199472739  rs193922365  rs199472740  rs199473466  rs199472741  rs120074186  rs120074181  rs199472742  rs120074195  rs199473467  rs199472743  rs199472745  rs199472746  rs120074182  rs199472747  rs120074184  rs199472748  rs120074184  rs120074184  rs74462309  rs74462309  rs199472749  rs104894255  rs199472749  rs199472751  rs199472752  rs199472753  rs199473470  rs199472753  rs199472754  rs199472755  rs199472756  rs199472759  rs199472759  rs12720459  rs12720459  rs12720459  rs199472760  rs199472761  rs199472761  rs199472762  rs199472763  rs199472763  rs120074183  rs199473471  rs199472764  rs199472765  rs199472824  rs199473402  rs199473403  rs199473404  rs199473406  rs199473407  rs199473407  rs12720458  rs199473409  rs199473410  rs199473410  rs199473411  rs199473412  rs199473472  rs199472766  rs199472767  rs199472768  rs199472771  rs199473473  rs199472772  rs199472773  rs199473474  rs199472774  rs199472775  rs12720457  rs199472776  rs199472777  rs267607197  rs199472780  rs12720449  rs12720449  rs199472782  rs140452381  rs199473476  rs199472783  rs199472784  rs199472785  rs17215500  rs145974930  rs145974930  rs199473479  rs199472789  rs199472790  rs120074188  rs199472791  rs199472792  rs199472793  rs199472794  rs199472795  rs199472796  rs199472797  rs199473480  rs199472798  rs199472799  rs199473481  rs120074185  rs199472800  rs120074185  rs199472801  rs199472804  rs199472803  rs199472804  rs199472805  rs199472805  rs199472807  rs199472808  rs199472809  rs199472810  rs17221854  rs199473482  rs199472812  rs120074189  rs120074190  rs199472813  rs199473483  rs199472814  rs199472815  rs199472815  rs199472816  rs34516117  rs147445322  rs397508101  rs199472819  rs199472821  rs199473484  rs1800172 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:18165683, ECO:0000269|PubMed:21228319, ECO:0000269|PubMed:22024150, ECO:0000269|PubMed:25037568};
Multi-pass membrane protein {ECO:0000269|PubMed:18165683}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18165683, ECO:0000269|PubMed:23529131}. Early endosome {ECO:0000269|PubMed:23529131}. Membrane raft {ECO:0000269|PubMed:20533308, ECO:0000269|PubMed:24855057}. Endoplasmic reticulum {ECO:0000269|PubMed:21228319, ECO:0000269|PubMed:24855057}. Basolateral cell membrane {ECO:0000269|PubMed:21228319}. Note=Colocalized with KCNE3 at the plasma membrane (PubMed:10646604). Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome (PubMed:23529131). Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains (PubMed:24855057). During the early stages of epithelial cell polarization induced by the calcium switch, it is removed from the plasma membrane to the endoplasmic reticulum, where it is retained, and redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage (PubMed:21228319). {ECO:0000269|PubMed:10646604, ECO:0000269|PubMed:21228319, ECO:0000269|PubMed:23529131, ECO:0000269|PubMed:24855057}.
Mouse PG classificationHPG
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