| Gene Information | |
|---|---|
| Gene Name | KCNN4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Intermediate conductance calcium-activated potassium channel protein 4 (SK4) (SKCa 4) (SKCa4) (IKCa1) (IK1) (KCa3.1) (KCa4) (Putative Gardos channel) |
| Target Name | calcium-activated potassium channel kca3.1 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000104783 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O15554 |
| Gene Card | KCNN4 |
| Uniprot ID | O15554 |
| Pfam | PF02888; PF07885; PF03530 |
| In ASD | yes |
| Allosteric Prediction | yes (1.116148925) |
| Ortholog in Animals | Alpaca_ KCNN4 ( ortholog_one2one ) Dog_ KCNN4 ( ortholog_one2one ) GuineaPig_ KCNN4 ( ortholog_one2one ) Macaque_ KCNN4 ( ortholog_one2one ) Mouse_ Kcnn4 ( ortholog_one2one ) Pig_ KCNN4 ( ortholog_one2one ) Rat_ Kcnn4 ( ortholog_one2one ) Rabbit_ KCNN4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNN3, KCNN1, KCNN2 |
| Tissue | minor.salivary.gland |
| Tissue Specificity | Widely expressed in non-excitable tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6CNM (EM 3.40A ) 6CNN (EM 3.50A ) 6CNO (EM 4.70A ) 6D42 (X-ray 1.75A ) |
| DBSNP | rs1057519077 rs1057519076 rs774455945 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:26148990}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | HPG |
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