| Gene Information | |
|---|---|
| Gene Name | MGST2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 147 |
| Protein Names | Microsomal glutathione S-transferase 2 (Microsomal GST-2) (EC 2.5.1.18) (Glutathione peroxidase MGST2) (EC 1.11.1.-) (Leukotriene C4 synthase MGST2) (EC 4.4.1.20) (Microsomal glutathione S-transferase II) (Microsomal GST-II) |
| Target Name | microsomal glutathione s-transferase 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000085871 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q99735 |
| Gene Card | MGST2 |
| Uniprot ID | Q99735 |
| Pfam | PF01124 |
| In ASD | no |
| Allosteric Prediction | no (-0.338055356) |
| Ortholog in Animals | Alpaca_ MGST2 ( ortholog_one2one ) Dog_ MGST2 ( ortholog_one2one ) GuineaPig_ MGST2 ( ortholog_one2one ) Macaque_ MGST2 ( ortholog_one2one ) Mouse_ Mgst2 ( ortholog_one2one ) Pig_ MGST2 ( ortholog_one2one ) Rat_ Mgst2 ( ortholog_one2one ) |
| Ohnologs | LTC4S |
| Paralogs | LTC4S, MGST3, ALOX5AP |
| Tissue | NA |
| Tissue Specificity | Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034). Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876). {ECO:0000269|PubMed:11322876, ECO:0000269|PubMed:8703034}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6SSR (X-ray 3.80A ) 6SSS (X-ray 2.50A ) 6SSU (X-ray 2.50A ) 6SSW (X-ray 3.00A ) |
| DBSNP | rs8192111 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:8703034}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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