| Gene Information | |
|---|---|
| Gene Name | SERPINF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Pigment epithelium-derived factor (PEDF) (Cell proliferation-inducing gene 35 protein) (EPC-1) (Serpin F1) |
| Target Name | pigment epithelium-derived factor |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000132386 ) 3 ( ENSG00000282307 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P36955 |
| Gene Card | SERPINF1 |
| Uniprot ID | P36955 |
| Pfam | PF00079 |
| In ASD | no |
| Allosteric Prediction | yes (0.508184097) |
| Ortholog in Animals | Alpaca_ SERPINF1 ( ortholog_one2one ) Dog_ SERPINF1 ( ortholog_one2one ) GuineaPig_ SERPINF1 ( ortholog_one2one ) Macaque_ SERPINF1 ( ortholog_one2one ) Mouse_ Serpinf1 ( ortholog_one2one ) Pig_ SERPINF1 ( ortholog_one2one ) Rat_ Serpinf1 ( ortholog_one2one ) Rabbit_ SERPINF1 ( ortholog_one2one ) |
| Ohnologs | SERPING1 |
| Paralogs | SERPING1, SERPINB7, SERPINI1, AGT, SERPIND1, SERPINA7, SERPINB8, SERPINA6, SERPINI2, HMSD, SERPINB6, SERPINC1, SERPINB1, SERPINA10, SERPINH1, SERPINB13, SERPINA3, SERPINA5, SERPINA9, SERPINA12, SERPINE1, SERPINF2, SERPINA4, SERPINB11, SERPINB5, SERPINB12, SERPINB9, SERPINE3, SERPINB4, SERPINB3, SERPINE2, SERPINA1, SERPINA2, SERPINB10, SERPINA11, SERPINB2 |
| Tissue | NA |
| Tissue Specificity | Retinal pigment epithelial cells and blood plasma. {ECO:0000269|PubMed:12737624}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IMV (X-ray 2.85A ) |
| DBSNP | rs1136287 rs1804145 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes. |
| Mouse PG classification | LPG |
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