| Gene Information | |
|---|---|
| Gene Name | KCNMB3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 279 |
| Protein Names | Calcium-activated potassium channel subunit beta-3 (BK channel subunit beta-3) (BKbeta3) (Hbeta3) (Calcium-activated potassium channel, subfamily M subunit beta-3) (Charybdotoxin receptor subunit beta-3) (K(VCA)beta-3) (Maxi K channel subunit beta-3) (Slo-beta-3) |
| Target Name | calcium-activated potassium channel |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000171121 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NPA1 |
| Gene Card | KCNMB3 |
| Uniprot ID | Q9NPA1 |
| Pfam | PF03185 |
| In ASD | no |
| Allosteric Prediction | no (-0.459922156) |
| Ortholog in Animals | Alpaca_ KCNMB3 ( ortholog_one2one ) Dog_ KCNMB3 ( ortholog_one2one ) GuineaPig_ KCNMB3 ( ortholog_one2one ) Macaque_ KCNMB3 ( ortholog_one2one ) Mouse_ Kcnmb3 ( ortholog_one2one ) Pig_ KCNMB3 ( ortholog_one2one ) Rat_ Kcnmb3 ( ortholog_one2one ) Rabbit_ KCNMB3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNMB2, KCNMB1, KCNMB4 |
| Tissue | NA |
| Tissue Specificity | Isoform 1, isoform 3 and isoform 4 are widely expressed. Isoform 2 is expressed placenta, pancreas, kidney and heart. Isoform 1 and isoform 3 are highly expressed in pancreas and testis. {ECO:0000269|PubMed:10585773, ECO:0000269|PubMed:10692449, ECO:0000269|PubMed:10766764}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1170672 rs7645550 rs2276802 rs55710741 rs145985409 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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