Gene Information
Gene NameKCNMA1
OrganismHomo sapiens (Human)
Gene Length1236
Protein NamesCalcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
Target Namecalcium-activated potassium channel kca1.1
Target TypeLiterature-reported target
Gene Age645 ( ENSG00000156113 )
Evolutionary StageEukaryota
AlphaFoldDBQ12791
Gene CardKCNMA1
Uniprot IDQ12791
PfamPF03493; PF00520
In ASDno
Allosteric Predictionyes (1.107979808)
Ortholog in AnimalsAlpaca_ KCNMA1 ( ortholog_one2one )
Dog_ KCNMA1 ( ortholog_one2one )
GuineaPig_ KCNMA1 ( ortholog_one2one )
Macaque_ KCNMA1 ( ortholog_one2one )
Mouse_ Kcnma1 ( ortholog_one2one )
Pig_ KCNMA1 ( ortholog_one2one )
Rat_ Kcnma1 ( ortholog_one2one )
Rabbit_ KCNMA1 ( ortholog_one2one )
OhnologsKCNU1
ParalogsKCNU1, KCNT1, KCNT2
TissueNA
Tissue SpecificityWidely expressed. Except in myocytes, it is almost ubiquitously expressed. {ECO:0000269|PubMed:11880513}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2K44  (NMR  -  )  3MT5  (X-ray  3.00A  )  3NAF  (X-ray  3.10A  )  6ND0  (EM  3.50A  )  6V22  (EM  3.20A  )  6V35  (EM  3.50A  )  6V38  (EM  3.80A  )  6V3G  (EM  4.00A  )  6V5A  (X-ray  2.00A  ) 
DBSNP rs1554829003  rs137853333  rs201996416  rs917980352  rs886039469  rs563967757 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288};
Multi-pass membrane protein {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}.
Mouse PG classificationLPG
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