| Gene Information | |
|---|---|
| Gene Name | XRCC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 633 |
| Protein Names | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000073050 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P18887 |
| Gene Card | XRCC1 |
| Uniprot ID | P18887 |
| Pfam | PF00533; PF16589; PF01834 |
| In ASD | no |
| Allosteric Prediction | yes (0.177409824) |
| Ortholog in Animals | Alpaca_ XRCC1 ( ortholog_one2one ) Dog_ XRCC1 ( ortholog_one2one ) GuineaPig_ XRCC1 ( ortholog_one2one ) Macaque_ XRCC1 ( ortholog_one2one ) Mouse_ Xrcc1 ( ortholog_one2one ) Pig_ XRCC1 ( ortholog_one2one ) Rat_ Xrcc1 ( ortholog_one2one ) Rabbit_ XRCC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | XNDC1N |
| Tissue | NA |
| Tissue Specificity | Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level). {ECO:0000269|PubMed:28002403}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1CDZ (X-ray 3.20A ) 1XNA (NMR - ) 1XNT (NMR - ) 2D8M (NMR - ) 2W3O (X-ray 1.85A ) 3K75 (X-ray 2.95A ) 3K77 (X-ray 2.60A ) 3LQC (X-ray 2.35A ) 5E6Q (X-ray 2.31A ) 5W7X (X-ray 2.00A ) 5W7Y (X-ray 2.10A ) 6WH1 (X-ray 2.40A ) 6WH2 (X-ray 2.41A ) |
| DBSNP | rs2307186 rs2307171 rs25496 rs2228487 rs2307180 rs2307191 rs1799782 rs25489 rs2307188 rs25490 rs25491 rs754041352 rs25487 rs761564262 rs2307184 rs25474 rs2307167 rs2307166 rs2682557 rs2307177 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:28002403}. Chromosome {ECO:0000269|PubMed:14500814}. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403). Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814). {ECO:0000269|PubMed:14500814, ECO:0000269|PubMed:28002403}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |