| Gene Information | |
|---|---|
| Gene Name | KCNMA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1236 |
| Protein Names | Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) |
| Target Name | calcium-activated potassium channel subunit alpha-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000156113 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q12791 |
| Gene Card | KCNMA1 |
| Uniprot ID | Q12791 |
| Pfam | PF03493; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (1.107979808) |
| Ortholog in Animals | Alpaca_ KCNMA1 ( ortholog_one2one ) Dog_ KCNMA1 ( ortholog_one2one ) GuineaPig_ KCNMA1 ( ortholog_one2one ) Macaque_ KCNMA1 ( ortholog_one2one ) Mouse_ Kcnma1 ( ortholog_one2one ) Pig_ KCNMA1 ( ortholog_one2one ) Rat_ Kcnma1 ( ortholog_one2one ) Rabbit_ KCNMA1 ( ortholog_one2one ) |
| Ohnologs | KCNU1 |
| Paralogs | KCNU1, KCNT1, KCNT2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Except in myocytes, it is almost ubiquitously expressed. {ECO:0000269|PubMed:11880513}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2K44 (NMR - ) 3MT5 (X-ray 3.00A ) 3NAF (X-ray 3.10A ) 6ND0 (EM 3.50A ) 6V22 (EM 3.20A ) 6V35 (EM 3.50A ) 6V38 (EM 3.80A ) 6V3G (EM 4.00A ) 6V5A (X-ray 2.00A ) |
| DBSNP | rs1554829003 rs137853333 rs201996416 rs917980352 rs886039469 rs563967757 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}; Multi-pass membrane protein {ECO:0000269|PubMed:20693285, ECO:0000269|PubMed:22399288}. |
| Mouse PG classification | LPG |
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