| Gene Information | |
|---|---|
| Gene Name | KCNK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 499 |
| Protein Names | Potassium channel subfamily K member 5 (Acid-sensitive potassium channel protein TASK-2) (TWIK-related acid-sensitive K(+) channel 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000164626 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O95279 |
| Gene Card | KCNK5 |
| Uniprot ID | O95279 |
| Pfam | PF07885 |
| In ASD | no |
| Allosteric Prediction | no (-0.039732066) |
| Ortholog in Animals | Alpaca_ KCNK5 ( ortholog_one2one ) Dog_ KCNK5 ( ortholog_one2one ) GuineaPig_ KCNK5 ( ortholog_one2one ) Macaque_ KCNK5 ( ortholog_one2one ) Mouse_ Kcnk5 ( ortholog_one2one ) Pig_ KCNK5 ( ortholog_one2one ) Rat_ Kcnk5 ( ortholog_one2one ) |
| Ohnologs | KCNK10, KCNK4, KCNK2, KCNK1 |
| Paralogs | KCNK6, KCNK15, KCNK3, KCNK13, KCNK1, KCNK17, KCNK9, KCNK2, KCNK18, KCNK16, KCNK12, KCNK7, KCNK4, KCNK10 |
| Tissue | NA |
| Tissue Specificity | Abundant expression in kidney, also detected in liver, placenta and small intestine. In the kidney, expression is restricted to the distal tubules and collecting ducts (PubMed:9812978). Not expressed in proximal tubules or glomeruli (PubMed:9812978). {ECO:0000269|PubMed:9812978}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs9462487 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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