| Gene Information | |
|---|---|
| Gene Name | KCNK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 426 |
| Protein Names | Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1) |
| Target Name | potassium channel subfamily k member 2 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000082482 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95069 |
| Gene Card | KCNK2 |
| Uniprot ID | O95069 |
| Pfam | PF07885 |
| In ASD | yes |
| Allosteric Prediction | yes (1.281335223) |
| Ortholog in Animals | Alpaca_ KCNK2 ( ortholog_one2one ) GuineaPig_ KCNK2 ( ortholog_one2one ) Macaque_ KCNK2 ( ortholog_one2one ) Mouse_ Kcnk2 ( ortholog_one2one ) Pig_ KCNK2 ( ortholog_one2one ) Rat_ Kcnk2 ( ortholog_one2one ) Rabbit_ KCNK2 ( ortholog_one2one ) |
| Ohnologs | KCNK16, KCNK6, KCNK10, KCNK17, KCNK5, KCNK4 |
| Paralogs | KCNK6, KCNK15, KCNK3, KCNK13, KCNK1, KCNK17, KCNK9, KCNK18, KCNK16, KCNK12, KCNK7, KCNK4, KCNK5, KCNK10 |
| Tissue | adrenal.gland |
| Tissue Specificity | Isoform 4 is detected in kidney, adrenal gland and brain where it is preferentially expressed in the amygdala but not found in thalamus, hypothalamus, hippocampus or substantia nigra. {ECO:0000269|PubMed:24196565}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4TWK (X-ray 2.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:23169818}; Multi-pass membrane protein {ECO:0000305}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:10784345}; Multi-pass membrane protein {ECO:0000305}.; [Isoform 4]: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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