| Gene Information | |
|---|---|
| Gene Name | KCNK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 367 |
| Protein Names | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (hKvbeta2) |
| Target Name | potassium channel subfamily k member 2 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000082482 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13303 |
| Gene Card | KCNAB2 |
| Uniprot ID | Q13303 |
| Pfam | PF00248 |
| In ASD | no |
| Allosteric Prediction | yes (1.281335223) |
| Ortholog in Animals | Alpaca_ KCNK2 ( ortholog_one2one ) GuineaPig_ KCNK2 ( ortholog_one2one ) Macaque_ KCNK2 ( ortholog_one2one ) Mouse_ Kcnk2 ( ortholog_one2one ) Pig_ KCNK2 ( ortholog_one2one ) Rat_ Kcnk2 ( ortholog_one2one ) Rabbit_ KCNK2 ( ortholog_one2one ) |
| Ohnologs | KCNK16, KCNK6, KCNK10, KCNK17, KCNK5, KCNK4 |
| Paralogs | KCNK6, KCNK15, KCNK3, KCNK13, KCNK1, KCNK17, KCNK9, KCNK18, KCNK16, KCNK12, KCNK7, KCNK4, KCNK5, KCNK10 |
| Tissue | adrenal.gland |
| Tissue Specificity | Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300). {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:7649300}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.030769(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ZSX (X-ray 1.90A ) 7EJ1 (EM 3.20A ) 7EJ2 (EM 3.30A ) 7WF3 (EM 3.40A ) 7WF4 (EM 3.40A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:P62483}. Membrane {ECO:0000269|PubMed:11086297, ECO:0000269|PubMed:21357749}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P62483}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:11086297}. Synapse, synaptosome {ECO:0000269|PubMed:21357749}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P62483}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated. {ECO:0000250|UniProtKB:P62483}. |
| Mouse PG classification | NA |
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