| Gene Information | |
|---|---|
| Gene Name | KCNK18 |
| Organism | Homo sapiens (Human) |
| Gene Length | 384 |
| Protein Names | Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) |
| Target Name | twik-related spinal cord potassium channel |
| Target Type | Literature-reported target |
| Gene Age | 424 ( ENSG00000186795 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q7Z418 |
| Gene Card | KCNK18 |
| Uniprot ID | Q7Z418 |
| Pfam | PF07885 |
| In ASD | no |
| Allosteric Prediction | yes (0.26387107) |
| Ortholog in Animals | Alpaca_ KCNK18 ( ortholog_one2one ) Dog_ KCNK18 ( ortholog_one2one ) GuineaPig_ KCNK18 ( ortholog_one2one ) Macaque_ KCNK18 ( ortholog_one2one ) Mouse_ Kcnk18 ( ortholog_one2one ) Rat_ Kcnk18 ( ortholog_one2one ) Rabbit_ KCNK18 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNK6, KCNK15, KCNK3, KCNK13, KCNK1, KCNK17, KCNK9, KCNK2, KCNK16, KCNK12, KCNK7, KCNK4, KCNK5, KCNK10 |
| Tissue | NA |
| Tissue Specificity | Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. {ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs3909165 rs363359 rs363315 rs363360 rs3026042 rs12247136 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:20006580}; Multi-pass membrane protein {ECO:0000269|PubMed:20006580}. |
| Mouse PG classification | NA |
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