Gene Information
Gene NameKCNK1
OrganismHomo sapiens (Human)
Gene Length336
Protein NamesPotassium channel subfamily K member 1 (Inward rectifying potassium channel protein TWIK-1) (Potassium channel K2P1) (Potassium channel KCNO1)
Target Namepotassium channel subfamily k member 1
Target TypeNA
Gene Age886 ( ENSG00000135750 )
Evolutionary StageEumetazoa
AlphaFoldDBO00180
Gene CardKCNK1
Uniprot IDO00180
PfamPF07885
In ASDno
Allosteric Predictionyes (0.808697716)
Ortholog in AnimalsAlpaca_ KCNK1 ( ortholog_one2one )
GuineaPig_ KCNK1 ( ortholog_one2one )
Macaque_ KCNK1 ( ortholog_one2one )
Mouse_ Kcnk1 ( ortholog_one2one )
Pig_ KCNK1 ( ortholog_one2one )
Rat_ Kcnk1 ( ortholog_one2one )
Rabbit_ KCNK1 ( ortholog_one2one )
OhnologsKCNK16, KCNK6, KCNK10, KCNK17, KCNK5, KCNK4
ParalogsKCNK6, KCNK15, KCNK3, KCNK13, KCNK17, KCNK9, KCNK2, KCNK18, KCNK16, KCNK12, KCNK7, KCNK4, KCNK5, KCNK10
TissueNA
Tissue SpecificityDetected in bronchial epithelial cells (PubMed:21964404). Detected in heart left atrium and left ventricle (PubMed:17478540). Detected in cardiac myocytes (at protein level) (PubMed:21653227). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed:8605869, PubMed:9362344). Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed:11165377). Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed:17478540). Detected in bronchial epithelial cells (PubMed:21964404). {ECO:0000269|PubMed:11165377, ECO:0000269|PubMed:17478540, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:21964404, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:9362344}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3UKM  (X-ray  3.40A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:15820677, ECO:0000269|PubMed:17693262, ECO:0000269|PubMed:20498050, ECO:0000269|PubMed:21653227, ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:22431633, ECO:0000269|PubMed:23169818, ECO:0000269|PubMed:25001086, ECO:0000269|PubMed:8605869, ECO:0000269|PubMed:8978667};
Multi-pass membrane protein {ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:8978667, ECO:0000305}. Recycling endosome {ECO:0000269|PubMed:19959478}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q9Z2T2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O08581}. Perikaryon {ECO:0000250|UniProtKB:O08581}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08581}. Cell projection {ECO:0000250|UniProtKB:O08581}. Apical cell membrane {ECO:0000269|PubMed:21964404};
Multi-pass membrane protein {ECO:0000305}. Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections. Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites. Detected at the apical cell membrane in stria vascularis in the cochlea. Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear. Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3. Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (By similarity). Detected at the apical cell membrane of bronchial epithelial cells (PubMed:21964404). {ECO:0000250|UniProtKB:O08581, ECO:0000250|UniProtKB:Q9Z2T2, ECO:0000269|PubMed:21964404}.
Mouse PG classificationNA
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