| Gene Information | |
|---|---|
| Gene Name | KCNJ8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 424 |
| Protein Names | ATP-sensitive inward rectifier potassium channel 8 (Inward rectifier K(+) channel Kir6.1) (Potassium channel, inwardly rectifying subfamily J member 8) (uKATP-1) |
| Target Name | mitochondrial atp-sensitive potassium channel |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000121361 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q15842 |
| Gene Card | KCNJ8 |
| Uniprot ID | Q15842 |
| Pfam | PF01007; PF17655 |
| In ASD | no |
| Allosteric Prediction | yes (0.725312431) |
| Ortholog in Animals | Alpaca_ KCNJ8 ( ortholog_one2one ) Dog_ KCNJ8 ( ortholog_one2one ) GuineaPig_ KCNJ8 ( ortholog_one2one ) Macaque_ KCNJ8 ( ortholog_one2one ) Mouse_ Kcnj8 ( ortholog_one2one ) Pig_ KCNJ8 ( ortholog_one2one ) Rat_ Kcnj8 ( ortholog_one2one ) Rabbit_ KCNJ8 ( ortholog_one2one ) |
| Ohnologs | KCNJ11 |
| Paralogs | KCNJ11, KCNJ15, KCNJ10, KCNJ13, KCNJ1, KCNJ14, KCNJ18, KCNJ4, KCNJ16, KCNJ12, KCNJ2, KCNJ9, KCNJ3, KCNJ5, KCNJ6 |
| Tissue | NA |
| Tissue Specificity | Predominantly detected in fetal and adult heart. {ECO:0000269|PubMed:9573340}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs606231263 rs606231264 rs34811413 rs147316959 rs72554071 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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