| Gene Information | |
|---|---|
| Gene Name | KCNJ6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 423 |
| Protein Names | G protein-activated inward rectifier potassium channel 2 (GIRK-2) (BIR1) (Inward rectifier K(+) channel Kir3.2) (KATP-2) (Potassium channel, inwardly rectifying subfamily J member 6) |
| Target Name | g protein-activated inward rectifier potassium channel 2 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000157542 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48051 |
| Gene Card | KCNJ6 |
| Uniprot ID | P48051 |
| Pfam | PF01007; PF17655 |
| In ASD | no |
| Allosteric Prediction | yes (0.586146305) |
| Ortholog in Animals | Alpaca_ KCNJ6 ( ortholog_one2one ) Dog_ KCNJ6 ( ortholog_one2one ) GuineaPig_ KCNJ6 ( ortholog_one2one ) Macaque_ KCNJ6 ( ortholog_one2one ) Mouse_ Kcnj6 ( ortholog_one2one ) Pig_ KCNJ6 ( ortholog_one2one ) Rat_ Kcnj6 ( ortholog_one2one ) Rabbit_ KCNJ6 ( ortholog_one2one ) |
| Ohnologs | KCNJ5, KCNJ9, KCNJ3, KCNJ14 |
| Paralogs | KCNJ5, KCNJ9, KCNJ3, KCNJ14, KCNJ18, KCNJ4, KCNJ16, KCNJ12, KCNJ2, KCNJ11, KCNJ15, KCNJ10, KCNJ13, KCNJ8, KCNJ1 |
| Tissue | NA |
| Tissue Specificity | Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.080000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs786204795 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | LPG |
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