| Gene Information | |
|---|---|
| Gene Name | KCNJ5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 419 |
| Protein Names | G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5) |
| Target Name | inward rectifier potassium channel kir3.4 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000120457 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P48544 |
| Gene Card | KCNJ5 |
| Uniprot ID | P48544 |
| Pfam | PF01007; PF17655 |
| In ASD | no |
| Allosteric Prediction | yes (1.190044417) |
| Ortholog in Animals | Alpaca_ KCNJ5 ( ortholog_one2one ) GuineaPig_ KCNJ5 ( ortholog_one2one ) Macaque_ KCNJ5 ( ortholog_one2one ) Mouse_ Kcnj5 ( ortholog_one2one ) Pig_ KCNJ5 ( ortholog_one2one ) Rat_ Kcnj5 ( ortholog_one2one ) Rabbit_ KCNJ5 ( ortholog_one2one ) |
| Ohnologs | KCNJ6, KCNJ4, KCNJ14, KCNJ12, KCNJ9 |
| Paralogs | KCNJ6, KCNJ9, KCNJ3, KCNJ14, KCNJ18, KCNJ4, KCNJ16, KCNJ12, KCNJ2, KCNJ11, KCNJ15, KCNJ10, KCNJ13, KCNJ8, KCNJ1 |
| Tissue | adrenal.gland, vas.deferens, spleen |
| Tissue Specificity | Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa. {ECO:0000269|PubMed:21311022}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs560269341 rs587777437 rs386352319 rs587777438 rs387906778 rs386352318 rs138295501 rs759363415 rs7102584 rs199830292 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:22315453, ECO:0000269|PubMed:24037882}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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