| Gene Information | |
|---|---|
| Gene Name | HAVCR1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell immunoglobulin mucin receptor 1) (TIM) (TIM-1) (T-cell membrane protein 1) (CD antigen CD365) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000113249 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96D42 |
| Gene Card | HAVCR1 |
| Uniprot ID | Q96D42 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.162541669) |
| Ortholog in Animals | Alpaca_ HAVCR1 ( ortholog_one2one ) Mouse_ BC053393 ( ortholog_one2many ) Mouse_ Timd2 ( ortholog_one2many ) Mouse_ Gm12169 ( ortholog_one2many ) Mouse_ Havcr1 ( ortholog_one2many ) Rat_ Timd2 ( ortholog_one2many ) Rat_ Havcr1 ( ortholog_one2many ) Rat_ Gm12169 ( ortholog_one2many ) Rat_ BC053393 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | TIMD4, MED7, HAVCR2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. {ECO:0000269|PubMed:9658108}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5DZO (X-ray 1.30A ) 5F70 (X-ray 1.80A ) |
| DBSNP | rs2270922 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:29742433}; Single-pass type I membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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