| Gene Information | |
|---|---|
| Gene Name | TPM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 284 |
| Protein Names | Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1) |
| Target Name | tropomyosin alpha-1 chain |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000140416 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P09493 |
| Gene Card | TPM1 |
| Uniprot ID | P09493 |
| Pfam | PF00261 |
| In ASD | no |
| Allosteric Prediction | yes (0.024405283) |
| Ortholog in Animals | Alpaca_ TPM1 ( ortholog_one2one ) Dog_ TPM1 ( ortholog_one2one ) GuineaPig_ TPM1 ( ortholog_one2one ) Macaque_ TPM1 ( ortholog_one2one ) Mouse_ Tpm1 ( ortholog_one2one ) Pig_ TPM1 ( ortholog_one2one ) Rat_ Tpm1 ( ortholog_one2one ) Rabbit_ TPM1 ( ortholog_one2one ) |
| Ohnologs | TPM4, TPM3, TPM2 |
| Paralogs | TPM3, TPM2, TPM4 |
| Tissue | NA |
| Tissue Specificity | Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle. {ECO:0000269|PubMed:15249230, ECO:0000269|Ref.15}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.0125(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3MUD (X-ray 2.20A ) 5KHT (X-ray 1.50A ) 6UT2 (NMR - ) 6X5Z (EM 4.24A ) |
| DBSNP | rs104894501 rs104894505 rs199476306 rs104894503 rs104894502 rs104894502 rs199476315 rs199476319 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04692}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P04692}. |
| Mouse PG classification | LPG |
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