| Gene Information | |
|---|---|
| Gene Name | KCNIP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 270 |
| Protein Names | Kv channel-interacting protein 2 (KChIP2) (A-type potassium channel modulatory protein 2) (Cardiac voltage-gated potassium channel modulatory subunit) (Potassium channel-interacting protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000120049 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9NS61 |
| Gene Card | KCNIP2 |
| Uniprot ID | Q9NS61 |
| Pfam | PF13499; PF13833 |
| In ASD | no |
| Allosteric Prediction | no (-0.231729004) |
| Ortholog in Animals | Alpaca_ KCNIP2 ( ortholog_one2one ) Dog_ KCNIP2 ( ortholog_one2one ) GuineaPig_ KCNIP2 ( ortholog_one2one ) Macaque_ KCNIP2 ( ortholog_one2one ) Mouse_ Kcnip2 ( ortholog_one2one ) Pig_ KCNIP2 ( ortholog_one2one ) Rat_ Kcnip2 ( ortholog_one2one ) Rabbit_ KCNIP2 ( ortholog_one2one ) |
| Ohnologs | KCNIP3, KCNIP1, KCNIP4 |
| Paralogs | KCNIP4, GUCA1B, VSNL1, KCNIP1, HPCAL1, NCS1, KCNIP3, GUCA1C, GUCA1A, RCVRN, CLXN, NCALD, HPCAL4, HPCA |
| Tissue | adipose.tissue, pineal.gland, heart |
| Tissue Specificity | Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart. {ECO:0000269|PubMed:11263977, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:15356203}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.166667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 7UKH (EM 2.33A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}. Note=Detected on lipid rafts (By similarity). {ECO:0000250|UniProtKB:Q9JM59}.; [Isoform 2]: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}.; [Isoform 6]: Cell membrane {ECO:0000250|UniProtKB:Q9JM59}; Lipid-anchor {ECO:0000250|UniProtKB:Q9JM59}. |
| Mouse PG classification | NA |
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