| Gene Information | |
|---|---|
| Gene Name | KCNH3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1083 |
| Protein Names | Potassium voltage-gated channel subfamily H member 3 (Brain-specific eag-like channel 1) (BEC1) (Ether-a-go-go-like potassium channel 2) (ELK channel 2) (ELK2) (Voltage-gated potassium channel subunit Kv12.2) |
| Target Name | voltage-gated potassium channel kv12.2 |
| Target Type | Literature-reported target |
| Gene Age | 987 ( ENSG00000135519 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9ULD8 |
| Gene Card | KCNH3 |
| Uniprot ID | Q9ULD8 |
| Pfam | PF00027; PF00520; PF13426 |
| In ASD | no |
| Allosteric Prediction | no (-0.029569353) |
| Ortholog in Animals | Alpaca_ KCNH3 ( ortholog_one2one ) Dog_ KCNH3 ( ortholog_one2one ) GuineaPig_ KCNH3 ( ortholog_one2one ) Macaque_ KCNH3 ( ortholog_one2one ) Mouse_ Kcnh3 ( ortholog_one2one ) Pig_ KCNH3 ( ortholog_one2one ) Rat_ Kcnh3 ( ortholog_one2one ) Rabbit_ KCNH3 ( ortholog_one2one ) |
| Ohnologs | KCNH4, KCNH6, KCNH2, KCNH8, KCNH7 |
| Paralogs | KCNH7, KCNH1, HCN3, CNGA3, HCN4, HCN2, KCNH8, HCN1, CNGB3, CNGB1, CNGA1, KCNH6, KCNH2, KCNH4, CNGA2, CNGA4, KCNH5 |
| Tissue | brain, cerebral.cortex, hippocampus |
| Tissue Specificity | Detected only in brain, in particular in the telencephalon. Detected in the cerebral cortex, occipital pole, frontal and temporal lobe, putamen, amygdala, hippocampus and caudate nucleus. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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