Gene Information
Gene NameKCNH1
OrganismHomo sapiens (Human)
Gene Length989
Protein NamesPotassium voltage-gated channel subfamily H member 1 (Ether-a-go-go potassium channel 1) (EAG channel 1) (h-eag) (hEAG1) (Voltage-gated potassium channel subunit Kv10.1)
Target Namepotassium voltage-gated channel subfamily h member 1
Target TypeNA
Gene Age645 ( ENSG00000143473 )
Evolutionary StageEukaryota
AlphaFoldDBO95259
Gene CardKCNH1
Uniprot IDO95259
PfamPF00027; PF00520; PF13426
In ASDno
Allosteric Predictionyes (0.888475052)
Ortholog in AnimalsAlpaca_ KCNH1 ( ortholog_one2one )
Dog_ KCNH1 ( ortholog_one2one )
GuineaPig_ KCNH1 ( ortholog_one2one )
Macaque_ KCNH1 ( ortholog_one2one )
Mouse_ Kcnh1 ( ortholog_one2one )
Pig_ KCNH1 ( ortholog_one2one )
Rat_ Kcnh1 ( ortholog_one2one )
Rabbit_ KCNH1 ( ortholog_one2one )
OhnologsKCNH5
ParalogsKCNH7, HCN3, CNGA3, KCNH3, HCN4, HCN2, KCNH8, HCN1, CNGB3, CNGB1, CNGA1, KCNH6, KCNH2, KCNH4, CNGA2, CNGA4, KCNH5
TissueNA
Tissue SpecificityHighly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.02(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5J7E  (X-ray  1.90A  ) 
DBSNP rs727502822  rs730882172  rs730882174  rs730882176  rs730882173  rs1553345948  rs727502819  rs730882175  rs727502821 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:21559285, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473};
Multi-pass membrane protein {ECO:0000269|PubMed:21559285}. Nucleus inner membrane {ECO:0000269|PubMed:21559285};
Multi-pass membrane protein {ECO:0000269|PubMed:21559285}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63472}. Cell projection, axon {ECO:0000250|UniProtKB:Q63472}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63472}. Perikaryon {ECO:0000250|UniProtKB:Q63472}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q63472}. Early endosome membrane {ECO:0000269|PubMed:22841712}. Note=Perinuclear KCNH1 is located to NPC-free islands.
Mouse PG classificationLPG
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