| Gene Information | |
|---|---|
| Gene Name | KCNG4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 519 |
| Protein Names | Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000168418 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TDN1 |
| Gene Card | KCNG4 |
| Uniprot ID | Q8TDN1 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | no (-0.102520632) |
| Ortholog in Animals | Alpaca_ KCNG4 ( ortholog_one2one ) Dog_ KCNG4 ( ortholog_one2one ) GuineaPig_ KCNG4 ( ortholog_one2one ) Macaque_ KCNG4 ( ortholog_one2one ) Mouse_ Kcng4 ( ortholog_one2one ) Pig_ KCNG4 ( ortholog_one2one ) Rat_ Kcng4 ( ortholog_one2one ) Rabbit_ KCNG4 ( ortholog_one2one ) |
| Ohnologs | KCNG1, KCNS1, KCNB1, KCNG2, KCNS2, KCNV1, KCNV2, KCNB2 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNS3, KCNS2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, and at lower levels in liver, small intestine and colon. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs35379218 rs11646443 rs17736370 rs4782905 rs7196482 rs35649980 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1 (PubMed:19074135). {ECO:0000269|PubMed:19074135}. |
| Mouse PG classification | NA |
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