| Gene Information | |
|---|---|
| Gene Name | KCNE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 129 |
| Protein Names | Potassium voltage-gated channel subfamily E member 1 (Delayed rectifier potassium channel subunit IsK) (IKs producing slow voltage-gated potassium channel subunit beta Mink) (Minimal potassium channel) |
| Target Name | potassium voltage-gated channel subfamily e member 1 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000180509 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P15382 |
| Gene Card | KCNE1 |
| Uniprot ID | P15382 |
| Pfam | PF02060 |
| In ASD | yes |
| Allosteric Prediction | yes (0.083996731) |
| Ortholog in Animals | Alpaca_ KCNE1 ( ortholog_one2one ) GuineaPig_ KCNE1 ( ortholog_one2one ) Mouse_ Kcne1 ( ortholog_one2one ) Pig_ KCNE1 ( ortholog_one2one ) Rat_ Kcne1 ( ortholog_one2one ) Rabbit_ KCNE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KCNE2 |
| Tissue | NA |
| Tissue Specificity | Expressed in lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Expressed in the heart (PubMed:19219384). Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. {ECO:0000269|PubMed:19219384, ECO:0000269|PubMed:9312006}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2K21 (NMR - ) |
| DBSNP | rs28933384 rs199473348 rs144917638 rs199473350 rs17857111 rs199473351 rs1805127 rs199473353 rs17173509 rs199473355 rs199473644 rs281865421 rs147187721 rs141813529 rs199473645 rs79654911 rs199473646 rs74315446 rs74315445 rs199473360 rs1805128 rs199473361 rs199473362 rs77442996 rs142511345 rs199473647 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:P15383}. Membrane raft {ECO:0000269|PubMed:20533308}. Note=Colocalizes with KCNB1 at the plasma membrane (By similarity). Targets to the membrane raft when associated with KCNQ1 (PubMed:20533308). {ECO:0000250|UniProtKB:P15383, ECO:0000269|PubMed:20533308}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |