| Gene Information | |
|---|---|
| Gene Name | KCND3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3) |
| Target Name | voltage-gated potassium channel kv4.3 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000171385 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UK17 |
| Gene Card | KCND3 |
| Uniprot ID | Q9UK17 |
| Pfam | PF02214; PF11879; PF00520; PF11601 |
| In ASD | no |
| Allosteric Prediction | yes (0.839706932) |
| Ortholog in Animals | Alpaca_ KCND3 ( ortholog_one2one ) Dog_ KCND3 ( ortholog_one2one ) GuineaPig_ KCND3 ( ortholog_one2one ) Macaque_ KCND3 ( ortholog_one2one ) Mouse_ Kcnd3 ( ortholog_one2one ) Pig_ KCND3 ( ortholog_one2one ) Rat_ Kcnd3 ( ortholog_one2one ) Rabbit_ KCND3 ( ortholog_one2one ) |
| Ohnologs | KCND1, KCND2 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in heart and brain, in particular in cortex, cerebellum, amygdala and caudate nucleus. Detected at lower levels in liver, skeletal muscle, kidney and pancreas. Isoform 1 predominates in most tissues. Isoform 1 and isoform 2 are detected at similar levels in brain, skeletal muscle and pancreas. {ECO:0000269|PubMed:10200233, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:9843794}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1S1G (X-ray 2.60A ) 2NZ0 (X-ray 3.20A ) |
| DBSNP | rs1349469134 rs797045634 rs397515476 rs397515477 rs397515478 rs786205867 rs150401343 rs149344567 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62897}. Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. {ECO:0000250|UniProtKB:Q62897}. |
| Mouse PG classification | NA |
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