Gene Information
Gene NameKCND2
OrganismHomo sapiens (Human)
Gene Length630
Protein NamesPotassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)
Target Namepotassium voltage-gated channel subfamily d member 2
Target TypeNA
Gene Age810 ( ENSG00000184408 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9NZV8
Gene CardKCND2
Uniprot IDQ9NZV8
PfamPF02214; PF11879; PF00520; PF11601
In ASDno
Allosteric Predictionyes (0.96369645)
Ortholog in AnimalsAlpaca_ KCND2 ( ortholog_one2one )
GuineaPig_ KCND2 ( ortholog_one2one )
Macaque_ KCND2 ( ortholog_one2one )
Mouse_ Kcnd2 ( ortholog_one2one )
Pig_ KCND2 ( ortholog_one2one )
Rat_ Kcnd2 ( ortholog_one2one )
Rabbit_ KCND2 ( ortholog_one2one )
OhnologsKCND1, KCND3
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
Tissuebrain, cerebral.cortex, cerebellar.hemisphere, cerebellum
Tissue SpecificityDetected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204). {ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:12395204, ECO:0000269|PubMed:15991246}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.030769(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7E7Z  (EM  3.20A  )  7E83  (EM  3.10A  )  7E87  (EM  3.40A  )  7E8B  (EM  4.20A  )  7E8E  (EM  3.90A  )  7E8H  (EM  4.50A  )  7F0J  (EM  2.90A  )  7F3F  (EM  3.10A  )  7UK5  (EM  2.76A  )  7UKC  (EM  3.00A  )  7UKD  (EM  2.88A  )  7UKE  (EM  3.01A  )  7UKF  (EM  3.02A  )  7UKG  (EM  2.24A  )  7UKH  (EM  2.33A  ) 
DBSNP rs587777631 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166};
Multi-pass membrane protein {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:14980201, ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:11102480}. Synapse {ECO:0000250|UniProtKB:Q63881}. Perikaryon {ECO:0000250|UniProtKB:Q63881}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q63881}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q63881}. Cell junction {ECO:0000250|UniProtKB:Q63881}. Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detected at cell junctions that are distinct from synaptic cell contacts. Detected in lipid rafts. Detected primarily at the endoplasmic reticulum or Golgi when expressed by itself (PubMed:15454437). Interaction with KCNIP1, KCNIP2, KCNIP3 or KCNIP4 promotes expression at the cell membrane (PubMed:15454437, PubMed:24811166). Interaction with DPP6 or DPP10 promotes expression at the cell membrane (By similarity). Internalized from the cell membrane by clathrin-dependent endocytosis in response to activation of AMPA-selective glutamate receptors and PKA-mediated phosphorylation at Ser-552. Redistributed from dendritic spines to the main dendritic shaft in response to activation of AMPA-selective glutamate receptors and activation of PKA (By similarity). {ECO:0000250|UniProtKB:Q63881, ECO:0000250|UniProtKB:Q9Z0V2, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:24811166}.
Mouse PG classificationNA
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