| Gene Information | |
|---|---|
| Gene Name | KCNC3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 757 |
| Protein Names | Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3) |
| Target Name | voltage-gated potassium channel kv3.3 |
| Target Type | Literature-reported target |
| Gene Age | 78 ( ENSG00000131398 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q14003 |
| Gene Card | KCNC3 |
| Uniprot ID | Q14003 |
| Pfam | PF02214; PF00520; PF11404 |
| In ASD | no |
| Allosteric Prediction | no (-0.043016467) |
| Ortholog in Animals | Alpaca_ KCNC3 ( ortholog_one2one ) Dog_ KCNC3 ( ortholog_one2one ) GuineaPig_ KCNC3 ( ortholog_one2one ) Macaque_ KCNC3 ( ortholog_one2one ) Mouse_ Kcnc3 ( ortholog_one2one ) Pig_ KCNC3 ( ortholog_one2one ) Rat_ Kcnc3 ( ortholog_one2one ) |
| Ohnologs | KCNC4, KCNC1, KCNC2 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs185017345 rs375912738 rs769502387 rs104894699 rs797044872 rs104894700 rs148033381 rs549394447 rs778523009 rs1460306526 rs958323371 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10712820, ECO:0000269|PubMed:16501573, ECO:0000269|PubMed:19953606, ECO:0000269|PubMed:21479265, ECO:0000269|PubMed:22289912, ECO:0000269|PubMed:23734863, ECO:0000269|PubMed:25152487, ECO:0000269|PubMed:25756792, ECO:0000269|PubMed:26997484}; Multi-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63959}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000250|UniProtKB:Q63959}. Cell projection, axon {ECO:0000250|UniProtKB:Q63959}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63959}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q01956}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26997484}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26997484}. Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484). {ECO:0000250|UniProtKB:Q01956, ECO:0000250|UniProtKB:Q63959, ECO:0000269|PubMed:26997484}. |
| Mouse PG classification | NA |
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