Gene Information
Gene NameKCNC2
OrganismHomo sapiens (Human)
Gene Length638
Protein NamesPotassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2)
Target Namevoltage-gated potassium channel kv3.2
Target TypeLiterature-reported target
Gene Age544 ( ENSG00000166006 )
Evolutionary StageEumetazoa
AlphaFoldDBQ96PR1
Gene CardKCNC2
Uniprot IDQ96PR1
PfamPF02214; PF00520
In ASDno
Allosteric Predictionyes (0.824932746)
Ortholog in AnimalsAlpaca_ KCNC2 ( ortholog_one2one )
Dog_ KCNC2 ( ortholog_one2one )
GuineaPig_ KCNC2 ( ortholog_one2one )
Macaque_ KCNC2 ( ortholog_one2one )
Mouse_ Kcnc2 ( ortholog_one2one )
Pig_ KCNC2 ( ortholog_one2one )
Rat_ Kcnc2 ( ortholog_one2one )
Rabbit_ KCNC2 ( ortholog_one2one )
OhnologsKCNC3, KCNC4, KCNC1
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
Tissuebrain, cerebral.cortex
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:15709110};
Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q14B80};
Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, axon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q14B80}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Synapse, synaptosome {ECO:0000250|UniProtKB:P22462}. Synapse {ECO:0000250|UniProtKB:P22462}. Apical cell membrane {ECO:0000250|UniProtKB:P22462}. Basolateral cell membrane {ECO:0000250|UniProtKB:P22462}. Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in starburst cell somata and proximal dendrite processes. Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons;
some of these patches are found near postsynaptic sites. {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q14B80}.
Mouse PG classificationNA
click here to return to the previous page