| Gene Information | |
|---|---|
| Gene Name | KCNC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | Potassium voltage-gated channel subfamily C member 2 (Shaw-like potassium channel) (Voltage-gated potassium channel Kv3.2) |
| Target Name | potassium voltage-gated channel subfamily c member 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000166006 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96PR1 |
| Gene Card | KCNC2 |
| Uniprot ID | Q96PR1 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (0.824932746) |
| Ortholog in Animals | Alpaca_ KCNC2 ( ortholog_one2one ) Dog_ KCNC2 ( ortholog_one2one ) GuineaPig_ KCNC2 ( ortholog_one2one ) Macaque_ KCNC2 ( ortholog_one2one ) Mouse_ Kcnc2 ( ortholog_one2one ) Pig_ KCNC2 ( ortholog_one2one ) Rat_ Kcnc2 ( ortholog_one2one ) Rabbit_ KCNC2 ( ortholog_one2one ) |
| Ohnologs | KCNC3, KCNC4, KCNC1 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:15709110}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q14B80}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, axon {ECO:0000250|UniProtKB:Q14B80}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q14B80}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Synapse, synaptosome {ECO:0000250|UniProtKB:P22462}. Synapse {ECO:0000250|UniProtKB:P22462}. Apical cell membrane {ECO:0000250|UniProtKB:P22462}. Basolateral cell membrane {ECO:0000250|UniProtKB:P22462}. Note=Colocalizes with parvalbumin in globus pallidus neurons. Localizes in thalamocortical axons and synapses. Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in starburst cell somata and proximal dendrite processes. Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites. {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q14B80}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |