Gene Information
Gene NameKCNB1
OrganismHomo sapiens (Human)
Gene Length858
Protein NamesPotassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)
Target Namepotassium voltage-gated channel subfamily b member 1
Target TypeNA
Gene Age680 ( ENSG00000158445 )
Evolutionary StageEumetazoa
AlphaFoldDBQ14721
Gene CardKCNB1
Uniprot IDQ14721
PfamPF02214; PF00520; PF03521
In ASDyes
Allosteric Predictionyes (0.9999249)
Ortholog in AnimalsAlpaca_ KCNB1 ( ortholog_one2one )
Dog_ KCNB1 ( ortholog_one2one )
GuineaPig_ KCNB1 ( ortholog_one2one )
Macaque_ KCNB1 ( ortholog_one2one )
Mouse_ Kcnb1 ( ortholog_one2one )
Pig_ KCNB1 ( ortholog_one2one )
Rat_ Kcnb1 ( ortholog_one2one )
Rabbit_ KCNB1 ( ortholog_one2one )
OhnologsKCNS2, KCNF1, KCNV1, KCNG4, KCNS3, KCNG2, KCNB2
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
Tissueadipose.tissue, brain, cerebral.cortex, pineal.gland
Tissue SpecificityExpressed in neocortical pyramidal cells (PubMed:24477962). Expressed in pancreatic beta cells (at protein level) (PubMed:12403834, PubMed:14988243). Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland (PubMed:19074135). Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra (PubMed:19074135). {ECO:0000269|PubMed:12403834, ECO:0000269|PubMed:14988243, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:24477962}.
Pharmacological Animal Models0.160618(Chimpanzee);0.079075(Mouse);NULL(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7RE5  (X-ray  2.50A  )  7SPD  (X-ray  2.70A  ) 
DBSNP rs1555889130  rs587777848  rs587777849  rs587777850  rs2229006  rs2229006  rs34467662  rs34280195 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:10484328, ECO:0000269|PubMed:11852086, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:12560340, ECO:0000269|PubMed:1283219, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:19223394, ECO:0000269|PubMed:19717558, ECO:0000269|PubMed:24477962, ECO:0000269|PubMed:24901643, ECO:0000269|PubMed:26503721, ECO:0000269|PubMed:8081723}. Perikaryon {ECO:0000269|PubMed:24477962}. Cell projection, axon {ECO:0000269|PubMed:24477962}. Cell projection, dendrite {ECO:0000269|PubMed:24477962}. Membrane;
Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P15387}. Synapse {ECO:0000250|UniProtKB:P15387}. Synapse, synaptosome {ECO:0000250|UniProtKB:P15387}. Lateral cell membrane {ECO:0000250|UniProtKB:P15387}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15387}. Note=Localizes to high-density somatodendritic clusters and non-clustered sites on the surface of neocortical and hippocampal pyramidal neurons in a cortical actin cytoskeleton-dependent manner (PubMed:24477962). Localizes also to high-density clusters in the axon initial segment (AIS), at ankyrin-G-deficient sites, on the surface of neocortical and hippocampal pyramidal neurons (PubMed:24477962). KCNB1-containing AIS clusters localize either in close apposition to smooth endoplasmic reticulum cisternal organelles or with GABA-A receptor-containing synapses of hippocampal and cortical pyramidal neurons, respectively (PubMed:24477962). Localizes to high-density clusters on the cell surface of atrial and ventricular myocytes and at the lateral plasma membrane in epithelial cells. Localizes both to the axial and transverse tubules (T tubule) and sarcolemma in ventricular myocytes. Associated with lipid raft domains. In cortical neurons, apoptotic injuries induce de novo plasma membrane insertion in a SNARE-dependent manner causing an apoptotic potassium current surge. {ECO:0000250|UniProtKB:P15387, ECO:0000250|UniProtKB:Q03717, ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135, ECO:0000269|PubMed:24477962, ECO:0000269|PubMed:24901643}.
Mouse PG classificationNA
click here to return to the previous page