| Gene Information | |
|---|---|
| Gene Name | KIAA0174 |
| Organism | Homo sapiens (Human) |
| Gene Length | 364 |
| Protein Names | IST1 homolog (hIST1) (Charged multivesicular body protein 8) (CHMP8) (Putative MAPK-activating protein PM28) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P53990 |
| Gene Card | IST1 |
| Uniprot ID | P53990 |
| Pfam | PF03398 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.490873(Rat);0.144391(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FRR (X-ray 1.80A ) 3FRS (X-ray 2.61A ) 3JC1 (EM 4.00A ) 4U7E (X-ray 1.60A ) 4U7I (X-ray 1.79A ) 4U7Y (X-ray 2.50A ) 4WZX (X-ray 1.39A ) 6E8G (EM 2.90A ) 6TZ4 (EM 3.20A ) 6TZ5 (EM 3.10A ) 6TZA (EM 7.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasmic vesicle {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20719964}. Midbody {ECO:0000269|PubMed:20719964}. Nucleus envelope {ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. Note=Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964). Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase. {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:20719964, ECO:0000269|PubMed:26040712, ECO:0000269|PubMed:28242692}. |
| Mouse PG classification | NA |
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