| Gene Information | |
|---|---|
| Gene Name | KCNA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 613 |
| Protein Names | Potassium voltage-gated channel subfamily A member 5 (HPCN1) (Voltage-gated potassium channel HK2) (Voltage-gated potassium channel subunit Kv1.5) |
| Target Name | voltage-gated potassium channel kv1.5 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000130037 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P22460 |
| Gene Card | KCNA5 |
| Uniprot ID | P22460 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (1.372592321) |
| Ortholog in Animals | Alpaca_ KCNA5 ( ortholog_one2one ) Dog_ KCNA5 ( ortholog_one2one ) GuineaPig_ KCNA5 ( ortholog_one2one ) Macaque_ KCNA5 ( ortholog_one2one ) Mouse_ Kcna5 ( ortholog_one2one ) Pig_ KCNA5 ( ortholog_one2one ) Rat_ Kcna5 ( ortholog_one2one ) Rabbit_ KCNA5 ( ortholog_one2one ) |
| Ohnologs | KCNA7, KCNA10, KCNA3, KCNA2, KCNA4 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | heart, aorta, atrium, coronary.artery, tibial.artery |
| Tissue Specificity | Pancreatic islets and insulinoma. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1056464 rs148708451 rs12720445 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:8505626}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | HPG |
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