Gene Information
Gene NameKCNA4
OrganismHomo sapiens (Human)
Gene Length653
Protein NamesPotassium voltage-gated channel subfamily A member 4 (HPCN2) (Voltage-gated K(+) channel HuKII) (Voltage-gated potassium channel HBK4) (Voltage-gated potassium channel HK1) (Voltage-gated potassium channel subunit Kv1.4)
Target Namepotassium voltage-gated channel subfamily a member 4
Target TypeNA
Gene Age3 ( ENSG00000182255 )
Evolutionary StageCellular_organisms
AlphaFoldDBP22459
Gene CardKCNA4
Uniprot IDP22459
PfamPF02214; PF00520; PF07941
In ASDno
Allosteric Predictionyes (0.785574053)
Ortholog in AnimalsDog_ KCNA4 ( ortholog_one2one )
GuineaPig_ KCNA4 ( ortholog_one2one )
Macaque_ KCNA4 ( ortholog_one2one )
Mouse_ Kcna4 ( ortholog_one2one )
Pig_ KCNA4 ( ortholog_one2one )
Rat_ Kcna4 ( ortholog_one2one )
Rabbit_ KCNA4 ( ortholog_one2one )
OhnologsKCNA7, KCNA1, KCNA5, KCNA6, KCNA10, KCNA3, KCNA2
ParalogsKCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2
TissueNA
Tissue SpecificityExpressed in brain, and at lower levels in the testis, lung, kidney, colon and heart (PubMed:27582084). Detected in heart ventricle. {ECO:0000269|PubMed:2001794, ECO:0000269|PubMed:27582084}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001990(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs779101828 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:19912772, ECO:0000269|PubMed:19968958, ECO:0000269|PubMed:8495559};
Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:P15385}.
Mouse PG classificationNA
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