| Gene Information | |
|---|---|
| Gene Name | KCNA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 575 |
| Protein Names | Potassium voltage-gated channel subfamily A member 3 (HGK5) (HLK3) (HPCN3) (Voltage-gated K(+) channel HuKIII) (Voltage-gated potassium channel subunit Kv1.3) |
| Target Name | voltage-gated potassium channel kv1.3 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000177272 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P22001 |
| Gene Card | KCNA3 |
| Uniprot ID | P22001 |
| Pfam | PF02214; PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (0.852507299) |
| Ortholog in Animals | Alpaca_ KCNA3 ( ortholog_one2one ) Dog_ KCNA3 ( ortholog_one2one ) GuineaPig_ KCNA3 ( ortholog_one2one ) Macaque_ KCNA3 ( ortholog_one2one ) Mouse_ Kcna3 ( ortholog_one2one ) Pig_ KCNA3 ( ortholog_one2one ) Rat_ Kcna3 ( ortholog_one2one ) |
| Ohnologs | KCNA7, KCNA1, KCNA5, KCNA6, KCNA4 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNQ4, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | appendix, lymph.node |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BGC (X-ray 1.20A ) 7EJ1 (EM 3.20A ) 7EJ2 (EM 3.30A ) 7SSV (EM 3.39A ) 7SSX (EM 2.89A ) 7SSY (EM 2.89A ) 7SSZ (EM 3.25A ) 8DFL (EM 3.25A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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