| Gene Information | |
|---|---|
| Gene Name | KCC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1139 |
| Protein Names | Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H2X9 |
| Gene Card | SLC12A5 |
| Uniprot ID | Q9H2X9 |
| Pfam | PF00324; PF03522 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Brain specific. Detected in neuronal cells. {ECO:0000269|PubMed:12106695}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6M23 (EM 3.20A ) 7D8Z (EM 3.40A ) |
| DBSNP | rs863225306 rs16985442 rs863225304 rs863225305 rs142740233 rs369042030 rs548424453 rs17297532 |
| Subcellular location [CC] | Cell projection, dendrite {ECO:0000250|UniProtKB:Q91V14}. Cell membrane {ECO:0000250|UniProtKB:Q91V14}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q91V14}. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses. {ECO:0000250|UniProtKB:Q91V14}. |
| Mouse PG classification | NA |
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