| Gene Information | |
|---|---|
| Gene Name | SEPTIN6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 434 |
| Protein Names | Septin-6 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000125354 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q14141 |
| Gene Card | SEPTIN6 |
| Uniprot ID | Q14141 |
| Pfam | PF00735 |
| In ASD | no |
| Allosteric Prediction | no (-0.757003244) |
| Ortholog in Animals | Alpaca_ SEPTIN6 ( ortholog_one2one ) Dog_ SEPTIN6 ( ortholog_one2one ) GuineaPig_ SEPTIN6 ( ortholog_one2one ) Macaque_ SEPTIN6 ( ortholog_one2one ) Mouse_ Septin6 ( ortholog_one2one ) Pig_ SEPTIN6 ( ortholog_one2one ) Rat_ Septin6 ( ortholog_one2one ) Rabbit_ SEPTIN6 ( ortholog_one2one ) |
| Ohnologs | SEPTIN11, SEPTIN8, SEPTIN10 |
| Paralogs | SEPTIN11, SEPTIN8, SEPTIN12, SEPTIN10, SEPTIN1, SEPTIN9, TMEM250, SEPTIN3, SEPTIN7, SEPTIN5, SEPTIN2, SEPTIN14 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:15915442}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2QAG (X-ray 4.00A ) 6UPA (X-ray 2.51A ) 6WBP (X-ray 1.80A ) 7M6J (EM 3.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830). {ECO:0000269|PubMed:25588830}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |