| Gene Information | |
|---|---|
| Gene Name | KAZN |
| Organism | Homo sapiens (Human) |
| Gene Length | 775 |
| Protein Names | Kazrin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000189337 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q674X7 |
| Gene Card | KAZN |
| Uniprot ID | Q674X7 |
| Pfam | PF00536; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-1.721756295) |
| Ortholog in Animals | Alpaca_ KAZN ( ortholog_one2one ) Dog_ KAZN ( ortholog_one2one ) Macaque_ KAZN ( ortholog_one2one ) Mouse_ Kazn ( ortholog_one2one ) Pig_ KAZN ( ortholog_one2one ) Rat_ Kazn ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level). {ECO:0000269|PubMed:15337775}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10803354 rs12048768 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250}.; [Isoform 2]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.; [Isoform 3]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures.; [Isoform 4]: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures. |
| Mouse PG classification | NA |
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