Gene Information
Gene NameKATNA1
OrganismHomo sapiens (Human)
Gene Length491
Protein NamesKatanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000186625 )
Evolutionary StageEuk_Archaea
AlphaFoldDBO75449
Gene CardKATNA1
Uniprot IDO75449
PfamPF00004; PF17862; PF09336
In ASDno
Allosteric Predictionno (-0.70418398)
Ortholog in AnimalsAlpaca_ KATNA1 ( ortholog_one2one )
Dog_ KATNA1 ( ortholog_one2one )
GuineaPig_ KATNA1 ( ortholog_one2one )
Macaque_ KATNA1 ( ortholog_one2one )
Mouse_ Katna1 ( ortholog_one2one )
Pig_ KATNA1 ( ortholog_one2one )
Rat_ Katna1 ( ortholog_one2one )
Rabbit_ KATNA1 ( ortholog_one2one )
OhnologsKATNAL1
ParalogsFIGNL2, VPS4A, FIGN, ATAD1, FIGNL1, KATNAL2, SPAST, VPS4B, KATNAL1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5ZQL  (X-ray  3.01A  )  5ZQM  (X-ray  2.90A  ) 
DBSNP NA 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Midbody {ECO:0000269|PubMed:19261606}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Predominantly cytoplasmic (PubMed:9658175). Localized diffusely in the cytoplasm during the interphase (PubMed:10751153). During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region (PubMed:19261606). Also localized to the interphase centrosome and the mitotic spindle poles (By similarity). Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1 (PubMed:10751153). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:19261606, ECO:0000269|PubMed:26929214, ECO:0000269|PubMed:9658175}.
Mouse PG classificationNA
click here to return to the previous page