| Gene Information | |
|---|---|
| Gene Name | KAT7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 611 |
| Protein Names | Histone acetyltransferase KAT7 (EC 2.3.1.48) (Histone acetyltransferase binding to ORC1) (Lysine acetyltransferase 7) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2) (MYST-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000136504 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O95251 |
| Gene Card | KAT7 |
| Uniprot ID | O95251 |
| Pfam | PF01853; PF01530; PF17772 |
| In ASD | no |
| Allosteric Prediction | no (-0.39169937) |
| Ortholog in Animals | Alpaca_ KAT7 ( ortholog_one2one ) Dog_ KAT7 ( ortholog_one2one ) GuineaPig_ KAT7 ( ortholog_one2one ) Macaque_ KAT7 ( ortholog_one2one ) Mouse_ Kat7 ( ortholog_one2one ) Pig_ KAT7 ( ortholog_one2one ) Rat_ Kat7 ( ortholog_one2one ) Rabbit_ KAT7 ( ortholog_one2one ) |
| Ohnologs | KAT8 |
| Paralogs | KAT8, KAT6B, KAT6A, PHF10, DPF1, DPF3, DPF2, RSF1, KAT5 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with highest levels in testis. {ECO:0000269|PubMed:10438470, ECO:0000269|PubMed:10930412}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5GK9 (X-ray 2.40A ) 6MAJ (X-ray 2.14A ) 6MAK (X-ray 2.13A ) 7D0O (X-ray 2.51A ) 7D0P (X-ray 1.80A ) 7D0Q (X-ray 2.21A ) 7D0R (X-ray 1.95A ) 7D0S (X-ray 2.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:28719581}. Chromosome {ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:28719581}. Chromosome, centromere {ECO:0000269|PubMed:27270040}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SVQ0}. Note=Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067, PubMed:20129055). Localizes to transcription start sites (PubMed:21753189, PubMed:24065767). Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581). Localizes to centromeres in G1 phase (PubMed:27270040). {ECO:0000269|PubMed:18832067, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:24065767, ECO:0000269|PubMed:27270040, ECO:0000269|PubMed:28719581}. |
| Mouse PG classification | NA |
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