| Gene Information | |
|---|---|
| Gene Name | IGF1R |
| Organism | Homo sapiens (Human) |
| Gene Length | 1367 |
| Protein Names | Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain] |
| Target Name | insulin-like growth factor i receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000140443 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P08069 |
| Gene Card | IGF1R |
| Uniprot ID | P08069 |
| Pfam | PF00757; PF07714; PF01030 |
| In ASD | yes |
| Allosteric Prediction | yes (1.669255138) |
| Ortholog in Animals | Alpaca_ IGF1R ( ortholog_one2one ) Dog_ IGF1R ( ortholog_one2one ) GuineaPig_ IGF1R ( ortholog_one2one ) Macaque_ IGF1R ( ortholog_one2one ) Mouse_ Igf1r ( ortholog_one2one ) Pig_ IGF1R ( ortholog_one2one ) Rat_ Igf1r ( ortholog_one2one ) Rabbit_ IGF1R ( ortholog_one2one ) |
| Ohnologs | INSR, INSRR |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. {ECO:0000269|PubMed:12019176, ECO:0000269|PubMed:8247543, ECO:0000269|PubMed:9202395, ECO:0000269|PubMed:9355755}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1IGR (X-ray 2.60A ) 1JQH (X-ray 2.10A ) 1K3A (X-ray 2.10A ) 1M7N (X-ray 2.70A ) 1P4O (X-ray 1.50A ) 2OJ9 (X-ray 2.00A ) 2ZM3 (X-ray 2.50A ) 3D94 (X-ray 2.30A ) 3F5P (X-ray 2.90A ) 3I81 (X-ray 2.08A ) 3LVP (X-ray 3.00A ) 3LW0 (X-ray 1.79A ) 3NW5 (X-ray 2.14A ) 3NW6 (X-ray 2.20A ) 3NW7 (X-ray 2.11A ) 3O23 (X-ray 2.10A ) 3QQU (X-ray 2.90A ) 4D2R (X-ray 2.10A ) 4XSS (X-ray 3.00A ) 5FXQ (X-ray 2.30A ) 5FXR (X-ray 2.40A ) 5FXS (X-ray 1.90A ) 5HZN (X-ray 2.20A ) 5U8Q (X-ray 3.27A ) 5U8R (X-ray 3.00A ) 6JK8 (EM 4.70A ) 6VWG (EM 3.21A ) 6VWH (EM 4.26A ) 6VWI (EM 3.70A ) 6VWJ (EM 4.21A ) 7PH8 (NMR - ) 7S0Q (EM 3.70A ) 7S8V (EM 3.73A ) 7V3P (EM 3.60A ) |
| DBSNP | rs121912426 rs121912427 rs45445894 rs34516635 rs33958176 rs56248469 rs45553041 rs121912429 rs34061581 rs35224135 rs45611935 rs141802822 rs34102392 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17524361}; Single-pass type I membrane protein {ECO:0000269|PubMed:17524361}. |
| Mouse PG classification | LPG |
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