| Gene Information | |
|---|---|
| Gene Name | CRASH |
| Organism | Homo sapiens (Human) |
| Gene Length | 308 |
| Protein Names | Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7L266 |
| Gene Card | ASRGL1 |
| Uniprot ID | Q7L266 |
| Pfam | PF01112 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma. {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:14654938}. |
| Pharmacological Animal Models | 0.050380(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3TKJ (X-ray 2.30A ) 4ET0 (X-ray 3.30A ) 4O0C (X-ray 1.50A ) 4O0D (X-ray 1.95A ) 4O0E (X-ray 1.71A ) 4O0F (X-ray 1.92A ) 4O0G (X-ray 2.10A ) 4O0H (X-ray 1.97A ) 4OSX (X-ray 1.95A ) 4OSY (X-ray 1.91A ) 4PVP (X-ray 1.85A ) 4PVQ (X-ray 2.13A ) 4PVR (X-ray 1.75A ) 4PVS (X-ray 1.84A ) 4ZM9 (X-ray 2.51A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11984834, ECO:0000269|PubMed:27106100}. Note=Midpiece of sperm tail. |
| Mouse PG classification | NA |
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