| Gene Information | |
|---|---|
| Gene Name | CREB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P15336 |
| Gene Card | ATF2 |
| Uniprot ID | P15336 |
| Pfam | PF00170 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed, with more abundant expression in the brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.229614(Rat);0.083971(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BHI (NMR - ) 1T2K (X-ray 3.00A ) 4H36 (X-ray 3.00A ) 6ZQS (X-ray 1.95A ) 6ZR5 (X-ray 2.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Cytoplasm. Mitochondrion outer membrane. Note=Shuttles between the cytoplasm and the nucleus and heterodimerization with JUN is essential for the nuclear localization. Localization to the cytoplasm is observed under conditions of cellular stress and in disease states. Localizes at the mitochondrial outer membrane in response to genotoxic stress. Phosphorylation at Thr-52 is required for its nuclear localization and negatively regulates its mitochondrial localization. Co-localizes with the MRN complex in the IR-induced foci (IRIF). |
| Mouse PG classification | NA |
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