| Gene Information | |
|---|---|
| Gene Name | SRGAP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1099 |
| Protein Names | SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (Mental disorder-associated GAP) (Rho GTPase-activating protein 14) (WAVE-associated Rac GTPase-activating protein) (WRP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000196220 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O43295 |
| Gene Card | SRGAP3 |
| Uniprot ID | O43295 |
| Pfam | PF00611; PF00620; PF00018 |
| In ASD | no |
| Allosteric Prediction | no (-0.339663921) |
| Ortholog in Animals | Alpaca_ SRGAP3 ( ortholog_one2one ) Dog_ SRGAP3 ( ortholog_one2one ) GuineaPig_ SRGAP3 ( ortholog_one2one ) Macaque_ SRGAP3 ( ortholog_one2one ) Mouse_ Srgap3 ( ortholog_one2one ) Pig_ SRGAP3 ( ortholog_one2one ) Rat_ Srgap3 ( ortholog_one2one ) |
| Ohnologs | ARHGAP4, SRGAP1 |
| Paralogs | ARHGAP4, SRGAP1, SRGAP2B, SRGAP2, SRGAP2C |
| Tissue | cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Highly expressed in adult and fetal brain. Expressed at low levels in kidney. Isoform 3 is expressed in the kidney but is absent in the brain. {ECO:0000269|PubMed:12195014, ECO:0000269|PubMed:12447388}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2271207 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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